---
title: "Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells"
description: "Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells — Nature Aging — 2026. DOI: 10.1038/s43587-026-01240-w"
datePublished: "2026-10-05"
lastmod: "2026-10-06T08:14:39+00:00"
authors:
  - "Rebecca Sereda"
  - "Kristen Lindenau"
  - "Antonio Diaz"
  - "Zhaohui Liu"
  - "Olaya Santiago-Fernández"
  - "Rabia R. Khawaja"
  - "Ronald Cutler"
  - "Jazmin Calyeca"
  - "Mericka McCabe"
  - "Sylvére Durand"
  - "Fanny Aprahamian"
  - "Natalia Del Pilar Vanegas"
  - "Hu Chen"
  - "Felipe Vilicich"
  - "Bhakti Chavda"
  - "Yair Botbol"
  - "Guido Kroemer"
  - "Toren Finkel"
  - "Evripidis Gavathiotis"
  - "Simone Sidoli"
  - "Ana L. Mora"
  - "Mauricio Rojas"
  - "Susmita Kaushik"
  - "Ana Maria Cuervo"
journal: "Nature Aging"
publisher: "Springer Science and Business Media LLC"
doi: "10.1038/s43587-026-01240-w"
publicationType: "journal-article"
schemaType: "ScholarlyArticle"
license: "https://creativecommons.org/licenses/by-nc-nd/4.0"
language: "en-GB"
slug: "10.1038-s43587-026-01240-w"
---

# Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

**Authors:** Rebecca Sereda, Kristen Lindenau, Antonio Diaz, Zhaohui Liu, Olaya Santiago-Fernández, Rabia R. Khawaja, Ronald Cutler, Jazmin Calyeca, Mericka McCabe, Sylvére Durand, Fanny Aprahamian, Natalia Del Pilar Vanegas, Hu Chen, Felipe Vilicich, Bhakti Chavda, Yair Botbol, Guido Kroemer, Toren Finkel, Evripidis Gavathiotis, Simone Sidoli, Ana L. Mora, Mauricio Rojas, Susmita Kaushik, Ana Maria Cuervo  
**Journal:** Nature Aging  
**Publisher:** Springer Science and Business Media LLC  
**Published:** 2026-10-05  
**DOI:** [10.1038/s43587-026-01240-w](https://dx.doi.org/10.1038/s43587-026-01240-w)

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